A two-cilia model for vertebrate left-right axis specification
نویسندگان
چکیده
منابع مشابه
A two-cilia model for vertebrate left-right axis specification.
The mechanisms underlying vertebrate left-right (L-R) axis specification have attracted much interest among developmental biologists (for review, see Burdine and Schier 2000; Capdevila et al. 2000). Of particular interest from a conceptual standpoint is the question of how L-R positional information first originates within the context of a bilaterally symmetric embryo. To achieve the consistent...
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Comparison between related species is a successful approach to uncover conserved and divergent principles of development. Here we studied the pattern of epithalamic asymmetry in zebrafish and medaka, two related teleost species with 115–200 million-year of independent evolution. We found that these species share a strikingly conserved overall pattern of asymmetry in the parapineal–habenular–int...
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Handed asymmetry of the shape and position of the internal organs is found in all vertebrates, and is essential for normal cardiac development. Recent genetic and embryological experiments in mouse embryos have demonstrated that left-right asymmetry is established by directional flow of extraembryonic fluid surrounding the node, which is driven by motile monocilia.
متن کاملVertebrate left-right development
Significant biological asymmetries range from the differentiation of sides within a single cell to the establishment of embryonic pattern across large fields of cells in multicellular organisms. One of the most intriguing biological asymmetries is left-right asymmetry in vertebrates. All vertebrates display a number of structures that are asymmetric along the left-right geometric body axis. The...
متن کاملLeft-right axis determination.
Vertebrates display left-right (L-R) asymmetric organ positioning and morphologies, which are established during embryonic development. These asymmetries are conserved among individuals and species. How, when and where do embryos first break the symmetry? Why is it broken in a consistent direction? How is the asymmetry transmitted to and coordinated within the whole embryo? Which of these eleme...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2003
ISSN: 0890-9369
DOI: 10.1101/gad.1053803